Protein Details: Acid-sensing ion channel 2

Protein ID

ICDB_Pro_1045

Protein Name

Acid-sensing ion channel 2

Gene Name

Asic2; Accn1; Bnac1; Mdeg

Organism

Rattus norvegicus (Rat)

Length

512 amino acids

AlphaFoldDB

AF-Q62962-F1-model_v4.pdb

Function

Cation channel with high affinity for sodium; which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Activation by an extracellular pH drop is followed by a rapid pH-independent inactivation. Heteromeric channel assembly seems to modulate channel properties.

Sequence

MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASLLTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 478: "Not glycosylated"; SITE 487: "Not glycosylated"

Disease

Location

Expressed in sciatic nerve and dorsal root ganglion (DRG) (at protein level). Both isoforms display the same expression pattern except in DRG where isoform 2 is more abundantly expressed. Widely distributed throughout the brain. Widely distributed throughout the brain. Widely distributed throughout the brain. Highly expressed in the main olfactory bulb; neo- and allo-cortical regions; hippocampal formation; habenula; basolateral amygdaloid nuclei; and cerebellum. In the olfactory system; expressed in the glomerular cell layer; the internal granular layer; and the mitral and internal plexiform cell layers. Within the glomerular layer; restricted to the periglomerular cells. In the neocortex; strongly expressed in the large pyramidal neurons in all cortical layers as well as in the oligo-; astro-; or micro-glia cells. In the hippocampal formation; expressed in dentate granule cells and hilar neurons; as well as in pyramidal cells of CA1-CA3 subfields. Expressed in stratum oriens and radiatum of all subfields. Within the thalamus; expressed moderately in the medial and lateral habenula. In the cerebellar cortex expressed in Purkinje cells and granule cells. Expressed at low levels in choroid plexus

DOI ID

10.1074/jbc.271.18.10433; 10.1074/jbc.272.47.29778; 10.1074/jbc.272.46.28819; 10.1074/jbc.m105208200; 10.1523/jneurosci.21-20-08026.2001; 10.1073/pnas.042688199; 10.1074/jbc.m313078200; 10.1074/jbc.m411849200; 10.1038/emboj.2012.203; 10.1038/ncomms1871; 10.1038/nature11494; 10.1016/j.toxicon.2013.04.008

RefSeq

NP_001029186.1 [Q62962-1]; NP_037024.2 [Q62962-2]